4/14/2023 0 Comments Count janos almazyUsing whole blood methylation data from 18 WS cases and 18 age matched controls, we find that WS is associated with increased extrinsic epigenetic age acceleration (p=0.0072) and intrinsic epigenetic age acceleration (p=0.04), the latter of which is independent of age-related changes in the composition of peripheral blood cells. While the underlying constitutional mutation leads to accelerated rates of DNA damage, it is not yet known whether WS is also associated with an increased epigenetic age according to a DNA methylation based biomarker of aging (the "Epigenetic Clock"). Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated aging. ![]() Maierhofer, Anna Flunkert, Julia Oshima, Junko Martin, George M Haaf, Thomas Horvath, Steve The expediency of using the following methods for the age rate estimation according to biologic age indices and necessity of prophylactic measures for premature and accelerated aging prevention among working population was demonstrated.Īccelerated epigenetic aging in Werner syndrome. The "risk group" with manifestations of accelerating aging was observed in 40-49-year old drivers with 15-19 years of professional experience. It was proved, that premature age-related changes of physiologic and psychophysiologic indices in drivers are just "risk indicators", while long driving experience is a real risk factor, accelerating the aging process. The results point at the premature decrease of the mental work capacity in professional drivers. Dynamics of the aging process of professional driver's organism in relation with calendar age and driving experience were shown using the biological age model. ![]() The examination revealed peculiarities of system organization of functions determining the mental work capacity levels. The studies of biological age, aging rate, mental work capacity in professional drivers were conducted.
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